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KMID : 0380020090240050425
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 5 p.425 ~ p.431
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Effects of Hepatocyte Growth Factor on the PSA Signaling Pathway of U-251-MG Cells
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Kim Hwan-Gyu
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Abstract
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Hepatocyte growth factor (HGF) and its receptor play an important role in the formation and progression of glioma. In this study, I investigated the ability of HGF to recover of the PSA siRNA-suppressed cell proliferation, migration and invasion in U-251-MG cells. PSA siRNA-transfected U-251-MG cells showed the reduction of the proliferation, migration and invasion with compared to control. Treatment of HGF on the PSA siRNA-transfected U-251-MG cells recovered the ability of proliferation, migration and invasion. These data suggest that PSA and HGF may use unique and parallel signaling cascade leading to the proliferative, migrative and invasive phenotype of U-251-MG cells. I also showed that PSA cooperated with HGF to a migrative and invasive phenotype via the increased secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9.
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KEYWORD
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PSA, HGF, MMP, plasmin
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